Flow Technology & Equipment-Asymchem Labs.

Development History

As a globally leading CDMO provider, Asymchem Laboratories has developed a systematic technology system in the innovation and application of continuous reaction technology and equipment. Leveraging its interdisciplinary strengths in chemical engineering, automation control, and intelligent manufacturing, the company continuously drives technology iteration, equipment innovation, process optimization, and industrial application. By replacing traditional batch reaction modes with continuous processes, it significantly enhances pharmaceutical efficiency and process safety, providing strong technical support for the global transformation of the pharmaceutical industry toward greener and smarter manufacturing.

2024

2023

2022

2021

2019

2017

2012

2010

2008

Continuous reaction technology achieved external technology output for tens of thousands of tons scale projects in the fine chemical field

Over 20 newly undertaken projects, process development, project undertaking, technology innovation and delivery capabilities continuously improving

Successfully developed the first domestic API continuous validation production project - continuous manufacturing of Metformin Hydrochloride

Participated in drafting the group standard 'Guidelines for Continuous Manufacturing of Active Pharmaceutical Ingredients and Intermediates'

Delivery of 500 ton low-temperature alkylation production project

The world's first American Chemical Society "CMO Green Chemistry Excellence Award" winning company

Over the past 10 years, we have invested more than 800 million RMB and successfully implemented over 300 continuous projects

Complete a commercial production project with a scale of 100 tons

Winning the Jilin Province Science and Technology Award: Development of a New Complete Continuous Technology and Its Industrial Application in the Pharmaceutical Field

Winning the China Patent Excellence Award: A Large Scale Continuous Safe Production Reactor for Diazomethane and Its Working Method

Realize continuous commercial scale application of ton level ozone oxidation on a continuous basis

Realize continuous application of kilogram level

Initiate continuous chemical research and development

Technical Services

Quickly and high quality solve chemical process problems Solves engineering control issues Resolves equipment and production issues

High throughput screening

Milligram level screening

150,000 reactions per year

Efficiency and quality improvement

Effectively support validation and supervision

Batch validation

Reaction condition confirmation

Gram scale process optimization

Process safety assessment

Continuous reaction experimentation and design

Continuous process optimization

Kinetics assessment

Engineering parameter evaluation

Continuous reactor design

Continuous reaction pilot testing

Pilot test

Scale up process validation

Simulation

Design and manufacture of continuous reaction system equipment

Equipment design/development

Equipment manufacturing

FAT (Factory Acceptance Test)

Assistance with installation and commissioning of production units

SAT acceptance

On site guidance

Technical training

Equipment Platforms

Through flexible combinations of various continuous reaction equipment platforms, achieves "close integration of process and equipment".

Liquid liquid reaction

Nitration

Chlorination

Bromination/iodination

Esterification

Curtius rearrangement

Aminolysis

Gas liquid reaction

Hydrogen peroxide oxidation

Peroxides

High temperature oxygen oxidation

Ozonolysis

Diazomethane preparation

Phosgenation

Homogeneous catalytic hydrogenation

Solid liquid reaction

Diazotization

Grignard reagent preparation

Grignard reaction

Zinc reagent preparation

Solid liquid nitration

Immobilized enzymes

Gas liquid solid reaction

Catalytic hydrogenation

Polymerization

Heterogeneous catalytic oxidation

Powder catalysts

Immobilized enzyme oxidation

Specialized reaction technologies

Photochemistry

Electrochemistry

Microwave

Ultrasound

Laser chemistry

Workup technologies

Filtration, online washing

Quenching, extraction

Distillation, distillation

Concentration, crystallization

Solid liquid separation

Membrane technology

Solvent recovery

Modular Commercial Production Lines

Annual output hundreds of tons scale continuous nitration reaction

Annual output hundreds of tons scale three step fully continuous substitution / ester hydrolysis / decarboxylation

Annual output hundreds of tons scale low temperature lithiation reaction

Annual output hundreds of tons scale continuous immobilized catalysis / continuous esterification

Annual output hundreds of tons scale chlorination reaction

Annual output thousands of tons scale continuous extraction post treatment

Self Developed Equipment and Instruments

Fully automatic peptide solid phase synthesizer

Oligonucleotide synthesizer

Online ammonolysis instrument

Tangential flow ultrafiltration instrument

Fully automatic integrated spray freeze drying apparatus

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