Stock Codes:
002821.SZ / 6821.HK
Global
Services & Solutions CDMO Core Technology Platforms Biocatalysis & Enzyme Engineering

Biocatalysis & Enzyme Engineering

Enzyme Engineering

Enzyme Engineering

With strong R&D strength and over ten years of technology accumulation and precipitation, Asymchem biosynthetic technology platform has successfully built a mature and comprehensive one stop synthetic biology service system. The platform fully covers all key links including enzyme route design, novel enzyme discovery, high throughput enzyme screening, enzyme evolution, enzyme immobilization, enzyme fermentation and enzyme catalyzed process development, demonstrating deep technical foundation and professional capabilities in the synthetic biology field, fully meeting clients' diversified and personalized needs.
14+

Over 14 years of experience accumulation

400+

Over 400 full time employees

260+

Over 260 patent applications

76,000+

Over 76,000m2 R&D / manufacturing base

A wide range of product types

Enzymes, fusion proteins, nanobodies, antibiotics, peptides, growth factors, interferons, cytokines, bio-based small molecules, etc.

A variety of efficient expression systems

E.coli, Pichia pastoris, Saccharomyces cerevisiae, Bacillus subtilis, etc.

Technology leading enzyme technology development platform

Proprietary protein big data and advanced AI protein design platform

High throughput screening and automation platform

Immobilized enzyme continuous biosynthesis

Enzyme evolution: performance improved by 50 times within 1 month

Enzyme library: over 300,000 mutant library (over 3,800 commonly used enzymes)

20 types of enzyme kits / 3 types of immobilized enzyme kits

Integrated chemical + enzyme catalysis green synthesis technology

We provide one stop enzyme catalysis solutions, through leading AI assisted enzyme evolution technology and advanced fermentation technology, sufficient fermentation capacity, combined with specific chemical processes, to reduce supply chain and cost risks, and create more environmentally friendly and more economical manufacturing processes.

Enzyme engineering

Enzyme route development

Enzyme discovery and development

Enzyme screening / enzyme evolution / enzyme immobilization

Enzyme fermentation

Fermentation process development

Purification process development

Fermentation production

Biotransformation

Enzyme catalysis process development

Bioconversion production

AI technology + automation + ultra high throughput

Enzyme catalysis replaces expensive precious metal catalysts, reduces chemical reaction steps, and significantly lowers production costs

Enzyme evolution: shortened from traditional about 1 month / round to 1 week / round evolution, achieving 50 times performance improvement within 1 month

Large proprietary enzyme library / mutant library: significantly improving screening efficiency

Proprietary DNA synthesis and sequencing platform: ensuring client IP information security

Immobilized enzyme and continuous reaction development: efficient development, significantly lowering production costs.

Widely applied to a wide range of products

Enzymatic routes for small molecule chiral intermediates (asymmetric reduction reactions of chiral hydroxyl / amino sulfides and alkenes, asymmetric oxidation reactions of chiral esters / acids, enzyme catalyzed synthesis of chiral secondary / tertiary amines, alkene epoxidation reactions, methylation reactions, etc.)

Peptides: ligases, proteases

Industrial enzymes

Oligonucleotides: ligases, polymerases

Biological drugs: proteases, transferases and more

Enzyme catalyzed synthesis

Production capacity
With a 16,500m2 modern production workshop, equipped with over 20,000L fermentation capacity system, capable of providing high quality gram scale to ton scale products. Capable of simultaneously meeting the manufacturing needs of various products including enzymes, recombinant proteins, peptides, bio based small molecules and other biological products at all stages.

Strain development and cell bank establishment

Culture medium design and screening

High density fermentation technology

1.5L×24 high throughput fermentation technology for rapid screening of optimal fermentation processes

Complete robust process development within 6 weeks

Fermentation process optimization following QbD design concept and DOE platform

Highly automated, intelligent and digitalized production system ensuring process stability

Independent upstream and downstream production areas

Multi scale complete equipment chain complying with GMP standards, meeting various scale production needs

High throughput chromatography media screening platform

Scalable separation and purification technology platform

Comprehensive quality management system

Scale Production line
Appropriate GMP 500L×4、5,000L×6
GMP 50L、500L、5,000L
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