Crystallization Engineering-Asymchem Labs.

Crystallization Engineering

The crystallization engineering team is dedicated to APIs, key intermediates and API excipient synergistic processes including chemical small molecules and macromolecules, providing professional technology R&D services, solving product quality control issues in R&D and production (such as crystal form, particle size, purity, flowability, etc.), eliminating scale up risks in the process (such as difficulty in filtration and drying, oiling out, wall adhesion, etc.), and ensuring production process stability. The team focuses on efficient and high quality technology development and production transformation. Every year, we undertake and complete over 500 crystallization step development and production implementation projects domestically and internationally.

Crystallization R&D Capabilities and Technologies

Process evaluation and optimization based on PAT technology

Online particle size analyzer

Online infrared

Online microscope

Control of crystal form, morphology, particle size, and flowability

Crystal form control

Crystal habit optimization

Particle size control

Improved flowability

Crystallization chiral resolution technology platform

A Classical diastereomeric salt resolution

B B.Crystallization induced kinetic resolution

C C.Ternary phase diagram guided chiral resolution

Complete 30+ chiral resolution R&D and production technology transfers annually

Macromolecule precipitation / crystallization process development platform

Replace freeze drying process

Computational simulation assisted process design and solvent screening

PAT based high throughput screening, optimization and scale up

Technology transfer and production scale up

Advantages

Effectively improves R&D efficiency and quality

Increases production capacity

Reduces production operation time and energy consumption

API excipient synergistic process

Heterogeneous nucleation

In situ granulation method

Polymer matrix crystallization method

Bridging agent regulation method

Advantages

Enables precise control of particle size across different specifications

Improves filtration and separation efficiency

Improves bulk density and flowability

Simplifies formulation development

Crystallization Research Equipment

X ray powder diffractometer Bruker D2

Wet Milling

Crystallization parallel screening instrument

Laser particle size analyzer Mastersizer 3000

Crystallization online equipment integrated combination Easymax+FBRM+EasyViewer+IR

Crystallization parallel screening apparatus CrystalSCAN

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Crystallization Engineering